Clinical Research

Clinical research is vital for developing and improving care and treatment for patients across the NHS.

Paxton Green is proud to be a Research Ready Accredited Practice.  We work collaboratively with the research arm of the NHS, the National Institute of Health Research Clinical Research Network (NIHR CRN), to participate in clinical research projects that can help improve people’s quality of life.  Our GP Research Lead is Dr Victoria Mayhew.  Paxton Green supports several types of Primary Care research studies all of which have received ethical approval.

If you are a patient at Paxton Green, you may receive invitation letters asking you if you wish to take part in a research study.  Patients at Paxton Green have participated in a wide range of different research studies and we are grateful to all those who have supported research at the practice over the years.  Participation in research projects is completely voluntary so if you do not wish to be contacted about research studies at the practice please click below:

Some research studies involve the research study team collecting data from medical records directly to study health conditions or the effectiveness of treatments across populations.  As a patient you have a right to opt out of your GP practice sharing data in this way, called a Type 1 Data Opt out.  For more information on this please click below:

Current Research Studies

Aspire DNA

The ASPIRE-DNA clinical trial is being run by Imperial College London and is investigating the effectiveness of a DNA-based diet on reducing the risk of developing Type 2 diabetes. Patients over the age of 18 who have had bloods tests in the past that have shown they might be at increased risk of diabetes (something called ‘pre-diabetes’) will be contacted by Paxton Green with information about the study via text message.

A DNA based diet is one where dietary advice is tailored to individuals based on their genetic traits. People who choose to take part in the trial will undergo a genetic test by taking some saliva from the inside of their cheek. This test will be analysed to identify a small number of genetic markers which might affect how their body absorbs and uses nutrients. This information will be used by the study team to provide dietary advice for trial participants.

Trial participants are randomly allocated to one of three groups of the trial. Some participants will receive their DNA results and subsequent dietary advice to improve their general health and identify any change in their glucose regulation. In addition, some participants will use an App to deliver this nutrition information. All participants will be monitored over the course of 12 weeks to identify any changes in glucose regulation (a primary indicator of diabetes risk), with a final follow up measurement at 26 weeks.

More information about the study can be found at:


This study is a randomised controlled trial of online Cognitive Therapy for young people with Post Traumatic Stress Disorder (PTSD). It is being run by a team of psychologists from Kings College London who specialise in the treatment of PTSD. They have developed a website and smartphone App for young people to use at home, with telephone support from a therapist. This new App can be used by children and young people aged 12-17 years old, who have developed PTSD after experiencing a one-off traumatic event, like an assault or a road traffic accident. The trial will compare online Cognitive Therapy using the new App and therapy website to a Waiting List (delayed therapy) condition.

For more information about the trial and whether you would be able to take part, please go to the trial website

COVID-19 Research Studies

Due to the COVID pandemic, many research studies are currently on hold.  However many people are keen to help research into treatments and vaccines for COVID-19 and may be interested in the following:


This study tests pre-existing antibiotic treatments to see if they improve symptoms and reduced hospital admission for people with COVID-19.  It is open to people aged 65+, or people aged 50-64 with certain underlying health conditions, with suspected or confirmed COVID-19 in the community.  For more information and to sign up see the attached information poster or go to the trial website

Researching a vaccine for COVID-19

There are a number of vaccines being identified and safety-tested at the moment, but only large scale studies can give researchers the information needed about how effective they are.  Researchers are looking for people from all backgrounds, ages and parts of the UK – including both people with or without existing health conditions – to take part in vaccine studies, to make sure that any vaccines developed will work for everyone.

If you are interested in helping with this research you can sign up for the NHS COVID-19 vaccine research registry.  The service is available to anyone aged 18 or over, living in the UK. There is no obligation to join in any study, if you are contacted. But by taking part, you could help researchers find vaccines to protect us all more quickly – which in turn could help the NHS and save lives.

Sign up today:

Further information about Clinical Trials can be found at the UK Clinical Trials website:

For more information about Clinical Research in the NHS visit the National Institute of Health Research website: